MEN syndrome mnemonic
Each of the MENs is a disease of three or two letters plus a feature.
“MEN I” is a disease of the 3 Ps (pituitary, parathyroid and pancreas).
“MEN II ” is a disease of the two Cs (carcinoma of the thyroid and catacholamines [pheochromocytoma]) plus parathyroid for MEN IIa or
mucocutaneous neuromas for MEN IIb (aka MEN III).
MEN I or MEN 1 (Wermer’s syndrome)
Mnemonic: 3 Ps
- Parathyroid hyperplasia
- Pancreatic islet cell tumor (Zollinger-Ellison syndrome in 50% and Insulinoma in 20%)
- Pituitary tumors
MEN II or MEN 2
Mnemonic: 2 Cs
Associated mutation: RET proto-oncogene
- Catecholamine releasing tumor: Pheochromocytoma
- Calcitonin releasing tumor: Medullary carcinoma of thyroid
Component specific to MEN IIA and MEN IIB:
- MEN IIA or 2A (Sipple’s syndrome): Parathyroid hyperplasia (hyperparathyroidism)
- MEN IIB or 2B (also called MEN III): Mucosal neuromas and Marfanoid habitus
MEN IV or MEN 4
MEN IV occurs due to mutation in CDKN1B.
Men IV syndrome is clinically indistinguishable from MEN I syndrome. In addition, these may have:
- Reproductive organ tumors (e.g. testicular tumors, neuroendocrine cervical carcinoma)
- Adrenal + Renal tumors
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Endocrinology: Adult and Pediatric By J. Larry Jameson, Leslie J. De Groot