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MEN syndrome mnemonic

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Multiple endocrine neoplasia medical mnemonic for USMLE / NCLEX.

Each of the MENs is a disease of three or two letters plus a feature.

“MEN I” is a disease of the 3 Ps (pituitary, parathyroid and pancreas).

“MEN II ” is a disease of the two Cs (carcinoma of the thyroid and catacholamines [pheochromocytoma]) plus parathyroid for MEN IIa or
mucocutaneous neuromas for MEN IIb (aka MEN III).

 

MEN I or MEN 1 (Wermer’s syndrome)

Mnemonic: 3 Ps

  1. Parathyroid hyperplasia
  2. Pancreatic islet cell tumor (Zollinger-Ellison syndrome in 50% and Insulinoma in 20%)
  3. Pituitary tumors

 

MEN II or MEN 2

Mnemonic: 2 Cs

Associated mutation: RET proto-oncogene

  1. Catecholamine releasing tumor: Pheochromocytoma
  2. Calcitonin releasing tumor: Medullary carcinoma of thyroid

Component specific to MEN IIA and MEN IIB:

  1. MEN IIA or 2A (Sipple’s syndrome): Parathyroid hyperplasia (hyperparathyroidism)
  2. MEN IIB or 2B (also called MEN III): Mucosal neuromas and Marfanoid habitus

 

MEN IV or MEN 4

MEN IV occurs due to mutation in CDKN1B.

Men IV syndrome is clinically indistinguishable from MEN I syndrome. In addition, these may have:

  1. Reproductive organ tumors (e.g. testicular tumors, neuroendocrine cervical carcinoma)
  2. Adrenal + Renal tumors

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Reference:

Endocrinology: Adult and Pediatric By J. Larry Jameson, Leslie J. De Groot

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