Alport Syndrome- Quick review for NEET PG



# Lets quickly discuss Alport’s syndrome for NEET PG.


# Alport syndrome is nephritic disorder characterised by the involvement of triad kidney, ear and eye.


# Fundamental defect in the a5- chain of collagen type IV.


# Light microscopy glomerular involvement in the form of the presence of foam cells in the interstitial cells.


# It shows presence of irregular foci of thickening and thinning in the GBM with splitting and lamination of lamina densa called as “basket weave appearance”. Absence of a5 staining is seen even on skin biopsy apart from glomerular and tubular basement membrane.


Hope you liked this brief discussion on important points about Alport syndrome. 

For any comments or suggestions please comment in below. 🙂

Give Us your Feedback : Comment Below